Agenus Inc. , a clinical-stage immuno-oncology company, focuses on the discovery and development of therapies that engage the body’s immune system to fight cancer. The company offers Retrocyte Display, an antibody discovery platform for the identification of fully-human and humanized monoclonal antibodies; SECANT yeast display, an antibody discovery platform used for the generation of novel monoclonal antibodies; and phage display technologies. It is also developing checkpoint modulating antibody candidates targeting GITR, OX40, TIM-3, LAG-3, and others. In addition, the company develops vaccine programs, including Prophage cancer vaccine candidate; AutoSynVax, a synthetic neo-antigen; and PhosPhoSynVax, a vaccine candidate designed to induce immunity against a class of tumor specific neo-epitopes. Further, it develops QS-21 Stimulon adjuvant, a saponin-based vaccine adjuvant. Additionally, the company engages in the development of CTLA-4 and PD-1 antagonists; and anti-CTLA-4, CD137, and anti-TIGIT antibodies, as well as various multi-specific antibodies that are under various stages of development. Agenus Inc. has collaboration agreements with Incyte Corporation, Merck Sharpe & Dohme, and Recepta Biopharma SA.; collaboration with Gilead Sciences, Inc. to develop immuno-oncology therapies; and partnership with Phyton Biotech. The company was formerly known as Antigenics Inc. and changed its name to Agenus Inc. in January 2011. Agenus Inc. was founded in 1994 and is headquartered in Lexington, Massachusetts.

  • Looking Into Agenus's Return On Capital Employed
    on September 18, 2020 at 2:13 pm

    Agenus (NASDAQ: AGEN) reported Q2 sales of $26.95 million. Earnings fell to a loss of $26.43 million, resulting in a 17.0% decrease from last quarter. Agenus collected $15.13 million in revenue during Q1, but reported earnings showed a $31.85 million loss.What Is ROCE? Changes in earnings and sales indicate shifts in Agenus's Return on Capital Employed, a measure of yearly pre-tax profit relative to capital employed in a business. Generally, a higher ROCE suggests successful growth in a company and is a sign of higher earnings per share for shareholders in the future. In Q2, Agenus posted an ROCE of 0.13%.It is important to keep in mind ROCE evaluates past performance and is not used as a predictive tool. It is a good measure of a company's recent performance, but several factors could affect earnings and sales in the near future.View more earnings on AGENROCE is an important metric for the comparison of similar companies. A relatively high ROCE shows Agenus is potentially operating at a higher level of efficiency than other companies in its industry. If the company is generating high profits with its current level of capital, some of that money can be reinvested in more capital which will lead to higher returns and earnings per share growth.For Agenus, the return on capital employed ratio shows the number of assets can actually help the company achieve higher returns, an important note investors will take into account when gauging the payoff from long-term financing strategies.Q2 Earnings Insight Agenus reported Q2 earnings per share at $-0.28/share, which did not meet analyst predictions of $-0.27/share.See more from Benzinga * Stocks That Hit 52-Week Highs On Friday * Return On Capital Employed Overview: Agenus * Stocks That Hit 52-Week Highs On Thursday(C) 2020 Benzinga.com. Benzinga does not provide investment advice. All rights reserved.

  • Agenus Initiates Rolling BLA Submission of Balstilimab for Recurrent/Metastatic Cervical Cancer
    on September 18, 2020 at 12:30 pm

    LEXINGTON, Mass., Sept. 18, 2020 (GLOBE NEWSWIRE) -- Agenus Inc. (NASDAQ: AGEN), an immuno-oncology company with an extensive pipeline of checkpoint antibodies, cell therapy, adjuvants, and vaccines designed to activate immune response to cancers and infections, announced the initiation of the rolling submission of its Biologics License Application (BLA) to the U.S. Food and Drug Administration (FDA) for balstilimab alone for the treatment of recurrent/metastatic cervical cancer. Data from the largest phase 2 trial of anti-PD-1 in patients with refractory cervical cancer was presented today at the European Society for Medical Oncology (ESMO) Virtual Congress https://agenusbio.com/balstilimab-balstilimab-zalifrelimab/.  Data from more than 160 patients treated with balstilimab (anti-PD-1) monotherapy achieved response rates of 19% in PD-L1 positive patients and 14% in all treated patients and will support the balstilimab BLA filing.Balstilimab is a novel anti-PD-1 human monoclonal antibody that has demonstrated promising clinical benefit in second line treatment of cervical cancer.“The initiation of the rolling BLA is an exciting step forward for Agenus as we are closer to making our therapies commercially available for patients with cervical cancer who have limited treatment options available,” said Dr. Jennifer Buell, President and COO of Agenus. “We continue to collaborate with the leading KOLs and the FDA in our efforts to make these treatments available to patients.”A rolling submission allows Agenus to submit each section of the BLA as it is completed, which enables the FDA to review the submitted sections in parallel with Agenus’s completion of the balance of the BLA application.The American Cancer Society estimates around 14,000 new cases of invasive cervical cancer to be diagnosed this year and nearly 4,300 cervical cancer deaths. This population needs new therapies that safely provide clinical benefit across all patients. About Agenus Agenus is a clinical-stage immuno-oncology company focused on the discovery and development of therapies that engage the body's immune system to fight cancer. The Company's vision is to expand the patient populations benefiting from cancer immunotherapy by pursuing combination approaches that leverage a broad repertoire of antibody therapeutics, adoptive cell therapies (through its AgenTus Therapeutics subsidiary), and proprietary cancer vaccine platforms. The Company is equipped with a suite of antibody discovery platforms and a state-of-the-art GMP manufacturing facility with the capacity to support clinical programs. Agenus is headquartered in Lexington, MA. For more information, please visit www.agenusbio.com and our Twitter handle @agenus_bio. Information that may be important to investors will be routinely posted on our website and Twitter.Forward-Looking StatementsThis press release contains forward-looking statements that are made pursuant to the safe harbor provisions of the federal securities laws, including statements regarding clinical development and regulatory plans and timelines. These forward-looking statements are subject to risks and uncertainties that could cause actual results to differ materially. These risks and uncertainties include, among others, the factors described under the Risk Factors section of our most recent Quarterly Report on Form 10-Q or Annual Report on Form 10-K filed with the Securities and Exchange Commission. Agenus cautions investors not to place considerable reliance on the forward-looking statements contained in this release. These statements speak only as of the date of this press release, and Agenus undertakes no obligation to update or revise the statements, other than to the extent required by law. All forward-looking statements are expressly qualified in their entirety by this cautionary statement.Contact: Agenus Inc.  Jennifer Buell, PhD 781-674-4420  Jennifer.Buell@agenusbio.com

  • Agenus Presents Results from Two Large Cervical Cancer Trials at ESMO
    on September 18, 2020 at 7:00 am

    * 160 patient balstilimab (PD-1) monotherapy trial achieves response rates of 14% in all treated patients and 19% in PD-L1 positive patients * 155 patient balstilimab (PD-1) + zalifrelimab (CTLA-4) combination trial achieves response rates of 22% in all patients and 27% in PD-L1 positive patientsLEXINGTON, Mass., Sept. 18, 2020 (GLOBE NEWSWIRE) -- Agenus Inc. (NASDAQ: AGEN), an immuno-oncology company with an extensive pipeline of checkpoint antibodies, cell therapy, adjuvants, and vaccines designed to activate immune response to cancers and infections, today presented preliminary results from two large clinical trials of more than 150 patients each at the European Society for Medical Oncology (ESMO) Virtual Congress 2020. Both trials were conducted in patients with recurrent/metastatic cervical cancer which has limited effective treatment options and disproportionately affects younger women.“Balstilimab has shown activity in both PD-L1 positive and negative tumors, suggesting that we may have a potentially differentiated PD-1,” said Dr. Garo Armen, Chairman and CEO of Agenus. “Furthermore, we have also shown important expansion in response rates, to near doubling in PD-L1 positive patients, and durability of response when patients receive zalifrelimab in combination with balstilimab.”The presentation was made by Dr. David O’Malley, Professor of Obstetrics and Gynecology at The Ohio State University College of Medicine and the Director of the Division of Gynecologic Oncology, The Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC – James). Dr. O’Malley is the lead investigator of the trials presented.“These trials represent the largest trials of immuno-oncology therapies in relapsed cervical cancer to date and show that balstilimab and zalifrelimab may present meaningful new therapies for patients with cervical cancer,” said Dr. O’Malley. “Advances in these agents offer renewed hope for patients who have limited treatment options.”Summary of Data Presented at ESMO2020 AGEN PD-1 Balstilimab n=160*AGEN PD-1 + CTLA-4 Balstilimab + Zalifrelimab n=143*   Response rates (ORR) PD-L1(+) PD-L1(-) 14% 19% 10% 22% 27% 11% ORR by tumor histology Squamous cell carcinoma   18% 27% Median duration of response (months) 15.4 months Not Reached *  mITT population; data cut-off: July 31, 2020 Agenus Presentation at ESMO Virtual Congress 2020:> Balstilimab (anti-PD-1) Alone and in Combination with Zalifrelimab (anti-CTLA-4) for Recurrent/Metastatic (R/M) Cervical Cancer (CC). Preliminary Results of Two Independent Ph2 Trials> > Author: O’Malley > Session: Mini Oral - Gynecological cancers 2 > Session Time: Friday, September 18 at 9:00 am CESTAbout Agenus Agenus is a clinical-stage immuno-oncology company focused on the discovery and development of therapies that engage the body's immune system to fight cancer. The Company's vision is to expand the patient populations benefiting from cancer immunotherapy by pursuing combination approaches that leverage a broad repertoire of antibody therapeutics, adoptive cell therapies (through its AgenTus Therapeutics subsidiary), and proprietary cancer vaccine platforms. The Company is equipped with a suite of antibody discovery platforms and a state-of-the-art GMP manufacturing facility with the capacity to support clinical programs. Agenus is headquartered in Lexington, MA. For more information, please visit www.agenusbio.com and our Twitter handle @agenus_bio. Information that may be important to investors will be routinely posted on our website and Twitter.Forward-Looking Statements This press release contains forward-looking statements that are made pursuant to the safe harbor provisions of the federal securities laws, including statements regarding the anticipated benefits of balstilimab and zalifrelimab based on preliminary results. These forward-looking statements are subject to risks and uncertainties that could cause actual results to differ materially. These risks and uncertainties include, among others, the factors described under the Risk Factors section of our most recent Quarterly Report on Form 10-Q or Annual Report on Form 10-K filed with the Securities and Exchange Commission. Agenus cautions investors not to place considerable reliance on the forward-looking statements contained in this release. These statements speak only as of the date of this press release, and Agenus undertakes no obligation to update or revise the statements, other than to the extent required by law. All forward-looking statements are expressly qualified in their entirety by this cautionary statement.Contact: Agenus Inc. Jennifer Buell, PhD 781-674-4420 Jennifer.Buell@agenusbio.com

  • Dr. Jennifer Buell Speaks Live at Scientific American Inaugural Fireside Chat Series 18 Minutes With
    on September 17, 2020 at 9:06 pm

    LEXINGTON, Mass., Sept. 17, 2020 (GLOBE NEWSWIRE) -- Agenus Inc. (NASDAQ: AGEN), an immuno-oncology company with an extensive pipeline of checkpoint antibodies, cell therapy, adjuvants, and vaccines designed to activate immune response to cancers and infections, today announced that Dr. Jennifer Buell, President and COO of Agenus, spoke to Jeremy Abbate, Publisher of Scientific American, in its inaugural fireside chat series 18 Minutes With on Wednesday September 16, 2020 at 4:00 p.m. EDT. A replay of the live streaming event 18 Minutes With: Dr. Jennifer Buell is available at https://www.scientificamerican.com/custom-media/cancer-covid-19-and-access-to-combination-therapies/In the interview with Jeremy Abbate, Dr. Buell discusses Agenus’ immunotherapies in the fight against COVID-19, the importance of combination therapies and the need for improved patient access, and the rapidly changing I-O landscape.About Agenus Agenus is a clinical-stage immuno-oncology company focused on the discovery and development of therapies that engage the body's immune system to fight cancer. The Company's vision is to expand the patient populations benefiting from cancer immunotherapy by pursuing combination approaches that leverage a broad repertoire of antibody therapeutics, adoptive cell therapies (through its AgenTus Therapeutics subsidiary), and proprietary cancer vaccine platforms. The Company is equipped with a suite of antibody discovery platforms and a state-of-the-art GMP manufacturing facility with the capacity to support clinical programs. Agenus is headquartered in Lexington, MA. For more information, please visit www.agenusbio.com and our Twitter handle @agenus_bio. Information that may be important to investors will be routinely posted on our website and Twitter.Contact: Agenus Inc.  Jennifer Buell, PhD 781-674-4420  Jennifer.Buell@agenusbio.com

  • Agenus to Participate in Webcast Hosted by William Blair on ESMO2020 Results and Novel Pipeline
    on September 17, 2020 at 5:38 pm

    LEXINGTON, Mass., Sept. 17, 2020 (GLOBE NEWSWIRE) -- Agenus Inc. (NASDAQ: AGEN), an immuno-oncology company with an extensive pipeline of checkpoint antibodies, cell therapy, adjuvants, and vaccines designed to activate immune response to cancers and infections, today announced that Dr. David O’Malley, expert in gynecologic oncology, and members of Agenus’ management team will participate in a webcast hosted by Dr. Matt Phipps of William Blair on Monday September 21, 2020 at 2:30 p.m. ET. Dr. David O’Malley will review data of balstilimab as a monotherapy and in combination with zalifrelimab presented at ESMO from the largest clinical trials of IO therapies in refractory cervical cancer, and he will discuss the potential of this proprietary combination.  Members of the Agenus management team will be available to discuss the next steps for balstilimab as monotherapy and in combination with zalifrelimab as well as the progress of other wholly-owned pipeline assets, such as Fc enhanced AGEN1181 and TIGIT monospecific and bispecific molecules.Investors, media and the general public can access a replay of the conference on Agenus’ website at https://investor.agenusbio.com/events-and-presentations.About Agenus Agenus is a clinical-stage immuno-oncology company focused on the discovery and development of therapies that engage the body's immune system to fight cancer. The Company's vision is to expand the patient populations benefiting from cancer immunotherapy by pursuing combination approaches that leverage a broad repertoire of antibody therapeutics, adoptive cell therapies (through its AgenTus Therapeutics subsidiary), and proprietary cancer vaccine platforms. The Company is equipped with a suite of antibody discovery platforms and a state-of-the-art GMP manufacturing facility with the capacity to support clinical programs. Agenus is headquartered in Lexington, MA. For more information, please visit www.agenusbio.com and our Twitter handle @agenus_bio. Information that may be important to investors will be routinely posted on our website and twitter.Forward-Looking Statements This press release contains forward-looking statements that are made pursuant to the safe harbor provisions of the federal securities laws, including statements regarding the potential and anticipated next steps for Agenus’ balstilimab and zalifrelimab, as well as the rest of its other pipeline assets. These forward-looking statements are subject to risks and uncertainties that could cause actual results to differ materially. These risks and uncertainties include, among others, the factors described under the Risk Factors section of our most recent Quarterly Report on Form 10-Q or Annual Report on Form 10-K filed with the Securities and Exchange Commission. Agenus cautions investors not to place considerable reliance on the forward-looking statements contained in this release. These statements speak only as of the date of this press release, and Agenus undertakes no obligation to update or revise the statements, other than to the extent required by law. All forward-looking statements are expressly qualified in their entirety by this cautionary statement.Contact:Agenus Inc.  Jennifer Buell, PhD 781-674-4420  Jennifer.Buell@agenusbio.com

  • Return On Capital Employed Overview: Agenus
    on September 11, 2020 at 2:28 pm

    During Q2, Agenus (NASDAQ: AGEN) brought in sales totaling $26.95 million. However, earnings decreased 17.0%, resulting in a loss of $26.43 million. In Q1, Agenus brought in $15.13 million in sales but lost $31.85 million in earnings.What Is ROCE? Return on Capital Employed is a measure of yearly pre-tax profit relative to capital employed in a business. Changes in earnings and sales indicate shifts in a company's ROCE. A higher ROCE is generally representative of successful growth in a company and is a sign of higher earnings per share for shareholders in the future. A low or negative ROCE suggests the opposite. In Q2, Agenus posted an ROCE of 0.13%.Keep in mind, while ROCE is a good measure of a company's recent performance, it is not a highly reliable predictor of a company's earnings or sales in the near future.View more earnings on AGENROCE is an important metric for the comparison of similar companies. A relatively high ROCE shows Agenus is potentially operating at a higher level of efficiency than other companies in its industry. If the company is generating high profits with its current level of capital, some of that money can be reinvested in more capital which will lead to higher returns and earnings per share growth.For Agenus, the return on capital employed ratio shows the number of assets can actually help the company achieve higher returns, an important note investors will take into account when gauging the payoff from long-term financing strategies.Q2 Earnings Insight Agenus reported Q2 earnings per share at $-0.28/share, which did not meet analyst predictions of $-0.27/share.See more from Benzinga * Stocks That Hit 52-Week Highs On Thursday(C) 2020 Benzinga.com. Benzinga does not provide investment advice. All rights reserved.

  • Why Agenus Is Soaring 23.6% Today
    on September 10, 2020 at 6:27 pm

    What happened Shares in Agenus (NASDAQ: AGEN) are rallying 23.65% at 2:10 pm EDT today ahead of a planned oral presentation of clinical trial data at the European Society of Medical Oncology (ESMO) Conference on Sept.

  • Paul Clark Joins Agenus Board of Directors
    on August 31, 2020 at 12:00 pm

    Agenus Inc. (NASDAQ: AGEN), an immuno-oncology company with an extensive pipeline of checkpoint antibodies, cell therapy, adjuvants, and vaccines designed to activate immune response to cancers and infections, today announced the election of Mr. Paul Clark to Agenus' Board of Directors.

  • Billionaire Israel Englander Goes Big on These 3 Penny Stocks
    on August 27, 2020 at 7:30 pm

    Penny stocks, they divide market watchers like no other. Some investors steer clear of these tickers going for less than $5 apiece, as poor fundamentals or overwhelming headwinds could be keeping them down in the dumps.On the other hand, penny stocks lure the more risk-tolerant. Not only does the bargain price tag mean you get more bang for your buck, but also even minor share price appreciation can yield huge percentage gains. The implication? Major returns for investors.Based on the above, weeding out the long-term underperformers from the penny stocks going for gold can pose a significant challenge. In this case, the activity of legendary stock pickers can provide some inspiration. Among these Wall Street titans is Israel “Izzy” Englander. Englander serves as the Chairman, CEO and Co-Chief Investment Officer of Millennium Management, the hedge fund he founded in 1989. Speaking to his impressive track record, he took the $35 million the fund was started with and grew it into $73 billion in assets under management. With this in mind, we used TipRanks’ database to find out what the analyst community has to say about three penny stocks that Englander's fund snapped up recently. As it turns out, each ticker has received only Buy ratings. Not to mention substantial upside potential is also on the table.Kindred Biosciences (KIN)Hoping to bring innovative biologics to veterinary medicine, Kindred Biosciences believes pets deserve the same kinds of safe and effective medicines that humans enjoy. At $3.78, Wall Street pros believe its share price could reflect the ideal entry point given everything the company has going for it.Englander is among the KIN fans. During Q2, Millenium pulled the trigger on 821,752 shares. As for the value of this new position, it comes in at $3,690,000.Also singing the healthcare name’s praises is Cantor analyst Brandon Folkes. “KIN has a pipeline of very good assets with the potential to generate significant value if they are brought to market,” Folkes explained. The analyst points out that there has been a strategy and priority shake-up over the last 12 months, but he believes the company's “pipeline of novel animal health drugs will drive long-term shareholder value beyond levels reflected in the current stock price.”The company continues to advance its biologics programs, including IL-31 and IL-4R antibodies for canine atopic dermatitis, KIND-030 for parvovirus in dogs and KIND-510a for the control of non-regenerative anemia in cats, together with long-acting versions of certain molecules, “all of which could be best-in-class large-market opportunities,” in Folkes’ opinion.Adding to the good news, Folkes sees its partnerships as helping to unlock value. These partnerships include a manufacturing agreement with Vaxart to manufacture Vaxart's oral vaccine candidate for COVID-19. Summing it all up, Folkes stated, “With animal health companies trading at 4.5-8.5x estimated 2021 revenue, and with business development playing a significant role in driving long-term growth for these larger animal health companies, we believe KIN's pipeline offers a unique suite of meaningful revenue opportunities for larger companies, if KIN can deliver on its pipeline's potential. We believe KIN's stock remains undervalued at current levels, and as 2020 progresses, we expect pipeline advancements to drive the stock higher.”To this end, Folkes rates KIN an Overweight (i.e. Buy) along with an $11 price target. Should his thesis play out, a potential twelve-month gain of 191% could be in the cards. (To watch Folkes’ track record, click here)Other analysts don’t beg to differ. With 4 Buy ratings and no Holds or Sells, the word on the Street is that KIN is a Strong Buy. The $11.50 average price target is more aggressive than Folkes’ and implies 208% upside potential. (See KIN stock analysis on TipRanks)Agenus Inc. (AGEN)Next up on our list is Agenus, which develops an immuno-oncology portfolio that includes checkpoint antibodies, cell therapies, vaccines and adjuvants. While this name, which changes hands for $4.02 apiece, has stayed relatively under the radar, some believe big things could be on the horizon.During Q2, Millenium made a major purchase. Scooping up 2,339,149 shares, the hedge fund’s new AGEN position is valued at $9,193,000. 5-star analyst Mayank Mamtani, of B.Riley FBR, has also been impressed. On August 6, AGEN provided an update regarding the progress of its pipeline. Its lead programs, AGEN2034 or balstilimab (bali; anti-PD1) and AGEN1884 or zalifrelimab (zali), are on track for separate BLA submissions, both in combination as well as bali as a monotherapy by YE20, in all-comer refractory/relapsed (r/r) cervical cancer.“Of note, within r/r cervical cancer, zali/bali is clinically de-risked and meaningfully differentiated relative to competing approaches in Merck's Keytruda and/or Iovance's TIL-based cell therapy; further, we view zali/bali to serve as an effective fast-follower to BMY's ipi/nivo across several tumor types with pricing optionality a key strategic leverage for AGEN to deploy upon market entry in 2021,” Mamtani explained.On top of this, AGEN1181, its multi T-cell and CTLA-4 engaging antibody which was Fc-engineered to overcome a genetic polymorphism in the CD16 allele, produced a strong result in the Phase 1 trial in MSS r/r endometrial cancer. After there was a CR generated by the AGEN1181 1 mg/kg monotherapy dose, AGEN1181 0.3 mg in combination with zali had a PR with ~80% tumor shrinkage change into a CR, as evidenced by a PET scan.“We are encouraged by AGEN identifying accelerated path to market by pursuing PD-1 refractory melanoma as well as ‘cold’ tumors in MSI-stable endometrial and colorectal cancer, and hepatocellular carcinoma, possibly in Phase 2 single-arm settings, as well as realize full potential longer term in large prevalence tumor types such as NSCLC and prostate cancer. On latter, AGEN's intent to establish AGEN1181 as preferred checkpoint inhibitor for combination therapy was recently validated by AACR'20 abstract demonstrating synergistic benefit with several therapeutic modalities,” Mamtani added. Bearing all of this in mind, Mamtani rates AGEN a Buy along with an $8 price target, which implies a 99% upside from current levels (To watch Mamtani’s track record, click here)Looking at the consensus breakdown, it has been quiet when it comes to other analyst activity. In the last three months, only 2 analysts have issued ratings. However, as they were both Buys, the word on the Street is that AGEN is a Moderate Buy. (See Agenus stock analysis on TipRanks)Marinus (MRNS)Last but not least is Marinus, which works on neuropsychiatric therapeutics and is considered a leader in orphan epileptic disorders. Currently going for $1.76 apiece, several members of the Street believe that it’s time to get in on the action.Englander is standing squarely with the bulls on this one. The billionaire’s fund bought up 934,155 shares in Q2. Reflecting a new position, the value of the holding lands at $2,373,000.Ahead of a fast-approaching data readout, Oppenheimer analyst Jay Olson is on board. Pivotal Phase 3 Marigold data for ganaxolone (GNX) in CDKL5 Deficiency Disorder (CDD) is scheduled for release any day now. The last patient visit for this trial took place in July, and the primary endpoint is seizure frequency reduction over 17-weeks for GNX versus placebo. “Prior Phase 2 open-label trial data show seizure frequency reduction of -44% at day-28 (N=7) and -54% at 6-months (N=4), suggesting durability, and low discontinuation rate of less than 10% in Phase 3 MARIGOLD suggests favorable tolerability,” Olson commented.However, Olson points out that this data release is being “overshadowed by long-term value drivers.” The first of these is the RSE pivotal Phase 3 trial of GNX, the design and dosing of which was confirmed in the EOP2 FDA meeting. MRNS still expects to kick off the trial in Q3 2020. Olson noted, “We view pivotal Phase 3 design as similar to positive Phase 2 trial while benefiting from longer dosing with 12 hours exposure vs. 8 hours prior. MRNS expects topline data in 1H22.”If that wasn’t enough, MRNS announced that patient screening had begun for the Tuberous sclerosis complex (TSC) Phase 2 trial of GNX, with the topline readout slated for 1Q21 with Allo-S biomarker analysis.Given everything MRNS has going for it, Olson rates the stock an Outperform (i.e. Buy) along with a $6 price target. This suggests that shares could move 237% higher in the next year. (To watch Olson’s track record, click here)It turns out that other analysts also like what they’re seeing. Only Buy ratings, 4 to be exact, have been received in the last three months, so the consensus rating is a Strong Buy. In addition, the $6.50 average price target indicates 263% upside potential. (See Marinus stock analysis on TipRanks)To find good ideas for penny stocks trading at attractive valuations, visit TipRanks’ Best Stocks to Buy, a newly launched tool that unites all of TipRanks’ equity insights.Disclaimer: The opinions expressed in this article are solely those of the featured analysts. The content is intended to be used for informational purposes only. It is very important to do your own analysis before making any investment.This article was originally posted on TipRanks.

  • Agenus Announces ESMO Oral Presentation of Two Clinical Trials of Balstilimab Alone and in Combination with Zalifrelimab in Recurrent or Metastatic Cervical Cancer
    on August 26, 2020 at 6:46 pm

    Agenus Inc. (NASDAQ: AGEN), an immuno-oncology company with an extensive pipeline of checkpoint antibodies, cell therapy, adjuvants, and vaccines designed to activate immune response to cancers and infections, today announced that data from two Phase 2 trials of balstilimab alone and in combination with zalifrelimab will be presented in an oral presentation at the upcoming European Society of Medical Oncology (ESMO) Conference on September 18, 2020.

Highlights of data featured in $AGEN #ESMO20 presentation. View full video on $AGEN website: https://agenusbio.com/balstilimab-balstilimab-zalifrelimab/ #oncology #immunotherapy

BREAKING! In metastatic cervical #cancer, Agenus advances efficacy with their complementary CTL4 and PD1 combo—27% response vs monotherapy 14% with #keytruda. @agenus_bio @jbuell01 #oncology #ESMO2020

$AGEN bal +/- zal at #ESMO show ORR of 19 & 27% in PD-L1 (+); PD-L1 (-) responders & favorable safety with treatment-related d/c 3.7 & 6.5% https://investor.agenusbio.com/news-releases/news-release-details/agenus-presents-results-two-large-cervical-cancer-trials-esmo

Agenus Initiates Rolling BLA Submission of Balstilimab for Recurrent/Metastatic Cervical Cancer https://investor.agenusbio.com/news-releases/news-release-details/agenus-initiates-rolling-bla-submission-balstilimab

Agenus Presents Results from Two Large Cervical Cancer Trials at ESMO https://investor.agenusbio.com/news-releases/news-release-details/agenus-presents-results-two-large-cervical-cancer-trials-esmo

Watch @jbuell01's full interview with @sciam here: https://buff.ly/3hJRW2a #immunotherapy #COVID__19 #18MinutesWith

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